PRODUCTION OF MULTIVESICULAR LIPOSOME

PROBLEM TO BE SOLVED: To provide an emulsifying method for preparing pharmaceutical preparations of multivesicular liposomes having characteristics of sustained release, and to provide pharmaceutical preparations produced by using the method. SOLUTION: Multivesicular liposomes are prepared at commer...

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Bibliographische Detailangaben
Hauptverfasser:	MEISSNER DAGMAR, PEPPER CLINT B, HARTOUNIAN HARTOUN
Format:	Patent
Sprache:	eng
Schlagworte:	BABY COMFORTERS CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES CONVEYING DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY DEVICES FOR RECEIVING SPITTLE DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS HANDLING THIN OR FILAMENTARY MATERIAL HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PACKING PERFORMING OPERATIONS PNEUMATIC TUBE CONVEYORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SHOP CONVEYOR SYSTEMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STORING TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING ORTIPPING TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an emulsifying method for preparing pharmaceutical preparations of multivesicular liposomes having characteristics of sustained release, and to provide pharmaceutical preparations produced by using the method. SOLUTION: Multivesicular liposomes are prepared at commercial scales by combining a first w/o emulsion with a second aqueous solution to form a w/o/w emulsion using a static mixer. Solvent is removed from the resulting emulsion to form multivesicular liposome-containing compositions. Further optional process steps include primary filtration and secondary cross-flow filtration. The produced products can be produced through a series of aseptic steps. COPYRIGHT: (C)2011,JPO&INPIT