HEMOSTATIC AND BLOOD COAGULATION INHIBITOR

PROBLEM TO BE SOLVED: To provide a hemostatic containing a compound which inhibits the function of ADAM8 as an active ingredient and to provide a blood coagulation inhibitor containing a compound which enhances the function of ADAM8 as an active ingredient. SOLUTION: It has been verified by using a...

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Bibliographische Detailangaben
Hauptverfasser:	IIDA ATSUO, SAKAGUCHI KAZUYA, SEHARA JUNKO, SATO KIYOAKI, KAWAHARA ATSUO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a hemostatic containing a compound which inhibits the function of ADAM8 as an active ingredient and to provide a blood coagulation inhibitor containing a compound which enhances the function of ADAM8 as an active ingredient. SOLUTION: It has been verified by using a living individual that blood circulation is inhibited by the inhibition of the expression of ADAM8, which leads to the formation of a thrombus and it has been found out that this molecule promotes blood circulation and has the activity of inhibiting the formation of a thrombus. Further, it has been elucidated that ADAM8 functions as a protease having a limited proteolytic activity of eliminating a selectin binding site for glycoprotein PSGL-1 associated with blood coagulation and blood cell transfer. COPYRIGHT: (C)2011,JPO&INPIT