HUMAN ANTIBODY THAT HAS MN BINDING AND CELL ADHESION-NEUTRALIZING ACTIVITY

PROBLEM TO BE SOLVED: To provide human antibodies that have MN binding and cell adhesion-neutralizing activities. SOLUTION: This invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of t...

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Hauptverfasser:	TAKEUCHI TOSHIHIKO, RINKENBERGER JULIE, DUBOIS-STRINGFELLOW NATHALIE, MURPHY JOHN E
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide human antibodies that have MN binding and cell adhesion-neutralizing activities. SOLUTION: This invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP repeats. The human MN antibodies or antibody fragments have been used to quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods, and to diagnose cancers in which MN is upregulated. An example is also provided where a human anti-MN IgG1 mediates tumor cell lysis through antibody-dependent cell-mediated cytotoxicity. Therefore, these antibodies will be useful for the treatment of cancers in which MN is upregulated or can be useful for the diagnosis of cancers in which MN is upregulated. COPYRIGHT: (C)2011,JPO&INPIT