MOLECULAR CONJUGATE FOR USE IN TREATMENT OF CANCER

PROBLEM TO BE SOLVED: To provide a composition of a Transferrin-drug conjugate for use in cancer treatment, a method of forming a molecular conjugate used for cancer treatment such as a transferrin-drug conjugate, and an intermediate used therefor. SOLUTION: There is provided the molecular conjugate having formula (I) wherein n is the conjugation number, P is a moiety of a carrier molecule such as a protein, R1is a moiety of a biologically active molecule or its analogs, derivatives, salts or secondary amines, Z is -O- or -NH-, and Y is a straight or branched 1C-20C alkyl optionally substituted with one or more phenyl, a cycloalkyl optionally substituted with one or more alkyl or phenyl, or an aromatic group optionally substituted with one or more alkyl, electron-withdrawing or electron-donating groups. Also there is provided a method of concentrating the biologically active molecule in selected target cells of a patient that comprises administering to the patient a selected dose of such molecular conjugate. COPYRIGHT: (C)2011,JPO&INPIT