FUSED PROTEIN HAVING BOTH FUNCTIONS OF THROMBOLYSIS AND ANTICOAGULATION AND USE THEREOF

FUSED PROTEIN HAVING BOTH FUNCTIONS OF THROMBOLYSIS AND ANTICOAGULATION AND USE THEREOF

PROBLEM TO BE SOLVED: To provide fused proteins having both functions of thrombolysis activity and anticoagulation activity. SOLUTION: The fused proteins having both functions of thrombolysis and anticoagulation, and a peptide making a junction therewith are provided, and especially, anticoagulation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHI BINGXING, YU AIPING, DONG CHUNNA, WU ZUZE
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide fused proteins having both functions of thrombolysis activity and anticoagulation activity. SOLUTION: The fused proteins having both functions of thrombolysis and anticoagulation, and a peptide making a junction therewith are provided, and especially, anticoagulation proteins and protein molecules having function of profibrinolysin activity, are provided. These are connected by the junction peptide having an amino acid sequence identified and to be cleaved by a coagulation factor. Furthermore, medical use of the fused protein and use of the junction peptide useful for connecting thrombolytic protein with anticoagulation protein and having the amino acid sequence identified by the coagulation factor, are provided. COPYRIGHT: (C)2010,JPO&INPIT