METHOD FOR PRODUCING (R)-alpha-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL

PROBLEM TO BE SOLVED: To provide various methods for producing (R)-α-(2,3-dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinemethanol. SOLUTION: There are provided various methods for the production comprising, reacting an (R)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol with a 4-fluorophenyleth...

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Hauptverfasser:	MINISH SHARON K, SKULTETY PAUL F, GUILAMOT GERARD, BINA ALAN G, ORTYL THOMAS T, HITT JAMES E, FLEMMING HANS-WOLFRAM, RAJEWSKI LIAN G, SACK MARVIN J, STOLTZ-DUNN SANDRA K, EVANS JONATHAN C, HAWTHORNE ROBERT A, DAUGS EDWARD D, KING CHI-HSIN R, TIGNER ALONZO L, KOEK JOHANNES N, TOMLINSON IAN A, MARGOLIN ALEXEY L, LASKOVICS FREDERICK M, LEFLER JOHN R, HILPERT THOMAS H E
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide various methods for producing (R)-α-(2,3-dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinemethanol. SOLUTION: There are provided various methods for the production comprising, reacting an (R)-α-(2,3-dimethoxyphenyl)-4-piperidinemethanol with a 4-fluorophenylethyl alkylating agent, reacting 4-[1-oxo-1-(2,3-dimethoxyphenyl)methyl]-N-2-(4-fluorofen-1-oxo-ethyl)piperidine with a chiral reducing agent, or a selective enzymatic hydrolysis of α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol butyric acid ester. COPYRIGHT: (C)2010,JPO&INPIT