HETEROARYL COMPOUND USEFUL AS INHIBITOR OF GSK-3

PROBLEM TO BE SOLVED: To provide a new therapeutic agent useful for treating various disorders, such as autoimmune disease, diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, multiple sclerosis (MS), schizophrenia, articular rheumatism and leukemia. SOLUTION: A chemical compound represented by formula I is useful as an inhibitor of GSK-3 or as an inhibitor of LCK protein kinase and is also useful for a method for boosting glycogen synthesis and/or for lowering the blood sugar level, especially useful for diabetic patients. The compound is also useful for a method for inhibiting the generation of phosphorylated excessive Tau and useful for stopping or delaying the progress of Alzheimer's disease. Another illustrative embodiment of this invention is associated with a method for inhibiting the phosphorylation of β-catenin and is useful for treating schizophrenia. COPYRIGHT: (C)2010,JPO&INPIT