MUTANT ACTINOSYNNEMA PRETIOSUM STRAIN INCREASING MAYTANSINOID PRODUCTION

MUTANT ACTINOSYNNEMA PRETIOSUM STRAIN INCREASING MAYTANSINOID PRODUCTION

PROBLEM TO BE SOLVED: To obtain a bacterial strain capable of reinforcing the production of maytansinoid, and reinforce so as to produce a sufficient amount of ansamitocin for making the easy commercial development of the bacterial strain, and a method, etc., for producing a plurality of maytansinoi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BYNG GRAHAM S, CHUNG JOHNSON
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To obtain a bacterial strain capable of reinforcing the production of maytansinoid, and reinforce so as to produce a sufficient amount of ansamitocin for making the easy commercial development of the bacterial strain, and a method, etc., for producing a plurality of maytansinoid ansamitocins by culturing the above in a proliferation medium containing a suitable carbon source. SOLUTION: This mutated bacterial strain of the Actinosynnema pretiosum named as PF4-4 (ATCC PTA-3921) is provided. The bacterial strain proliferates under various culturing conditions and produces the maytansinoid ansamitocins such as ansamitocin P-3, in improved yields as compared with those of conventionally known strains. COPYRIGHT: (C)2010,JPO&INPIT