SUBSTITUTED TETRACYCLINE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel substituted tetracycline compound useful to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms. SOLUTION: The compound is represented by formula (I), wherein X is CH2, CH-alkyl or the like; R2, R2', R3, R10,...

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Hauptverfasser:	BHATIA BEENA, NIHLAWI MOHAMMED, FRECHETTE ROGER, BANDARAGE UPUL, OHEMENG KWASI, ASSEFA HAREGEWEIN, NELSON MARK L, REDDY LAXMA, KIM OAK A, ABATO PAUL, VISKI PETER, HONEYMAN LAURA, BERNIAC JOEL, ISMAIL MOHAMED Y, MECHICHE RACHID, AMOO VICTOR, MATHEWS JUDE, PEARSON ANDRE, VERMA ATUL K, WARCHOL TADEUSZ, SHEAHAN PAUL, CHEN JACKSON, SIZENSKY EMMANUELLE, TOURIGNY JUSTIN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a novel substituted tetracycline compound useful to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms. SOLUTION: The compound is represented by formula (I), wherein X is CH2, CH-alkyl or the like; R2, R2', R3, R10, R11and R12are hydrogen or the like; R4is dimethylamino or the like; R5is hydrogen or the like; R7is hydrogen, carboxyl, amino, cyano, phenyl that may be substituted, a heterocycle or the like; R8is hydrogen or the like; and R9is hydrogen, alkyl, amino or the like. COPYRIGHT: (C)2010,JPO&INPIT