INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA
PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for ex...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | PAULSEN HOLGER LEE WENDY KHIRE UDAY RIEDL BERND SMITH ROGER A WOOD JILL E REDMAN ANIKO LOWINGER TIMOTHY BRUNO DUMAS JACQUES HATOUM-MOKDAD HOLIA JOHNSON JEFFREY SCOTT WILLIAM J |
| description | PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2010065041A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2010065041A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2010065041A3</originalsourceid><addsrcrecordid>eNrjZLD09PPwdPIM8fRzVwhydFPw9vRzDHZVCA0GCQSHOgWHeIaEhri6KHi4hrgG-TtHOvt4OiuEBrk68jCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeK8AIwNDAwMzUwMTQ0djohQBAO2_KUQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA</title><source>esp@cenet</source><creator>PAULSEN HOLGER ; LEE WENDY ; KHIRE UDAY ; RIEDL BERND ; SMITH ROGER A ; WOOD JILL E ; REDMAN ANIKO ; LOWINGER TIMOTHY BRUNO ; DUMAS JACQUES ; HATOUM-MOKDAD HOLIA ; JOHNSON JEFFREY ; SCOTT WILLIAM J</creator><creatorcontrib>PAULSEN HOLGER ; LEE WENDY ; KHIRE UDAY ; RIEDL BERND ; SMITH ROGER A ; WOOD JILL E ; REDMAN ANIKO ; LOWINGER TIMOTHY BRUNO ; DUMAS JACQUES ; HATOUM-MOKDAD HOLIA ; JOHNSON JEFFREY ; SCOTT WILLIAM J</creatorcontrib><description>PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100325&DB=EPODOC&CC=JP&NR=2010065041A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20100325&DB=EPODOC&CC=JP&NR=2010065041A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PAULSEN HOLGER</creatorcontrib><creatorcontrib>LEE WENDY</creatorcontrib><creatorcontrib>KHIRE UDAY</creatorcontrib><creatorcontrib>RIEDL BERND</creatorcontrib><creatorcontrib>SMITH ROGER A</creatorcontrib><creatorcontrib>WOOD JILL E</creatorcontrib><creatorcontrib>REDMAN ANIKO</creatorcontrib><creatorcontrib>LOWINGER TIMOTHY BRUNO</creatorcontrib><creatorcontrib>DUMAS JACQUES</creatorcontrib><creatorcontrib>HATOUM-MOKDAD HOLIA</creatorcontrib><creatorcontrib>JOHNSON JEFFREY</creatorcontrib><creatorcontrib>SCOTT WILLIAM J</creatorcontrib><title>INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA</title><description>PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLD09PPwdPIM8fRzVwhydFPw9vRzDHZVCA0GCQSHOgWHeIaEhri6KHi4hrgG-TtHOvt4OiuEBrk68jCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeK8AIwNDAwMzUwMTQ0djohQBAO2_KUQ</recordid><startdate>20100325</startdate><enddate>20100325</enddate><creator>PAULSEN HOLGER</creator><creator>LEE WENDY</creator><creator>KHIRE UDAY</creator><creator>RIEDL BERND</creator><creator>SMITH ROGER A</creator><creator>WOOD JILL E</creator><creator>REDMAN ANIKO</creator><creator>LOWINGER TIMOTHY BRUNO</creator><creator>DUMAS JACQUES</creator><creator>HATOUM-MOKDAD HOLIA</creator><creator>JOHNSON JEFFREY</creator><creator>SCOTT WILLIAM J</creator><scope>EVB</scope></search><sort><creationdate>20100325</creationdate><title>INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA</title><author>PAULSEN HOLGER ; LEE WENDY ; KHIRE UDAY ; RIEDL BERND ; SMITH ROGER A ; WOOD JILL E ; REDMAN ANIKO ; LOWINGER TIMOTHY BRUNO ; DUMAS JACQUES ; HATOUM-MOKDAD HOLIA ; JOHNSON JEFFREY ; SCOTT WILLIAM J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2010065041A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2010</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PAULSEN HOLGER</creatorcontrib><creatorcontrib>LEE WENDY</creatorcontrib><creatorcontrib>KHIRE UDAY</creatorcontrib><creatorcontrib>RIEDL BERND</creatorcontrib><creatorcontrib>SMITH ROGER A</creatorcontrib><creatorcontrib>WOOD JILL E</creatorcontrib><creatorcontrib>REDMAN ANIKO</creatorcontrib><creatorcontrib>LOWINGER TIMOTHY BRUNO</creatorcontrib><creatorcontrib>DUMAS JACQUES</creatorcontrib><creatorcontrib>HATOUM-MOKDAD HOLIA</creatorcontrib><creatorcontrib>JOHNSON JEFFREY</creatorcontrib><creatorcontrib>SCOTT WILLIAM J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PAULSEN HOLGER</au><au>LEE WENDY</au><au>KHIRE UDAY</au><au>RIEDL BERND</au><au>SMITH ROGER A</au><au>WOOD JILL E</au><au>REDMAN ANIKO</au><au>LOWINGER TIMOTHY BRUNO</au><au>DUMAS JACQUES</au><au>HATOUM-MOKDAD HOLIA</au><au>JOHNSON JEFFREY</au><au>SCOTT WILLIAM J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA</title><date>2010-03-25</date><risdate>2010</risdate><abstract>PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_JP2010065041A |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T19%3A37%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PAULSEN%20HOLGER&rft.date=2010-03-25&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJP2010065041A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |