INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA

INHIBITING RAF KINASE USING SUBSTITUTED HETEROCYCLIC UREA

PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for ex...

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Hauptverfasser: PAULSEN HOLGER, LEE WENDY, KHIRE UDAY, RIEDL BERND, SMITH ROGER A, WOOD JILL E, REDMAN ANIKO, LOWINGER TIMOTHY BRUNO, DUMAS JACQUES, HATOUM-MOKDAD HOLIA, JOHNSON JEFFREY, SCOTT WILLIAM J
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide an isooxazolyl urea compound having an activity of inhibiting RAF kinase, useful in treating solid cancer, for example a cancerous tumor [such as a cancerous tumor of a lung, spleen, thyroid, bladder, or colon, or a disease of bone marrow (bone marrow leukemia for example)], or an adenoma (a villus-like colon adenoma, for example), or the like. SOLUTION: The compound is represented by the following formula (in the formula, R1 is selected from the group consisting of 3-10C alkyl, 3-10C cycloalkyl, 3-10C halosubstituted alkyl up to perhaloalkyl and 3-10C halosubstituted cycloalkyl up to perhalocycloalkyl, and B represents phenyl, phenyl substituted with pyridyl or -Y-Ar, pyridinyl, indolinyl, isoquinolinyl, quinolinyl or naphthyl). COPYRIGHT: (C)2010,JPO&INPIT