INHIBITOR OF GSK-3, AND CRYSTAL STRUCTURE OF GSK-3beta PROTEIN, AND PROTEIN COMPLEX

PROBLEM TO BE SOLVED: To find an inhibitor of GSK-3 effective as a therapeutic agent. SOLUTION: Inhibitors of glycogen synthase (glycogen synthase) kinase-3 (GSK-3) and serine/threonine protein kinase, and a method for producing the same are provided. Furthermore, a pharmaceutical composition compri...

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Hauptverfasser:	SWENSON LOVORKA, GREEN JEREMY, ARNOST MICHAEL J, TER HAAR ERNST
Format:	Patent
Sprache:	eng
Schlagworte:	AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUSPOLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CRYSTAL GROWTH CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REFINING BY ZONE-MELTING OF MATERIAL SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITHDEFINED STRUCTURE SINGLE-CRYSTAL-GROWTH SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL ORUNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To find an inhibitor of GSK-3 effective as a therapeutic agent. SOLUTION: Inhibitors of glycogen synthase (glycogen synthase) kinase-3 (GSK-3) and serine/threonine protein kinase, and a method for producing the same are provided. Furthermore, a pharmaceutical composition comprising the inhibitor, and a method for using the composition in treatment and prevention of various disease states (e.g. diabetes and Alzheimer's disease) are provided. COPYRIGHT: (C)2010,JPO&INPIT