INTESTINAL TRACT PROTEASE AND UTILIZATION OF THE SAME

INTESTINAL TRACT PROTEASE AND UTILIZATION OF THE SAME

PROBLEM TO BE SOLVED: To provide a bio-marker diagnosing (the abnormality of) intestinal tract, especially colitis in an early stage. SOLUTION: The characteristics of intestinal proteases are shown by preparing a sodium dextran sulfate-induced mouse colitis model. The intestinal proteases showing a...

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Hauptverfasser: AOKI NATSUKO, OMURA TAKEO, TAKAHASHI YOSHIKI
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator AOKI NATSUKO
OMURA TAKEO
TAKAHASHI YOSHIKI
description PROBLEM TO BE SOLVED: To provide a bio-marker diagnosing (the abnormality of) intestinal tract, especially colitis in an early stage. SOLUTION: The characteristics of intestinal proteases are shown by preparing a sodium dextran sulfate-induced mouse colitis model. The intestinal proteases showing a negative high correlation to inflammation intensity, and the protease hydrolyzing the arginine C-terminal of an X-phenylalanine-arginine-4-methyl-cumaryl-7-amide are provided from the intestines having different inflammation intensity, wherein, the X is any of benzyloxycarbonyl or L-proline. COPYRIGHT: (C)2010,JPO&INPIT
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title INTESTINAL TRACT PROTEASE AND UTILIZATION OF THE SAME
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