NEW PEPTIDE AS NS3-SERINE PROTEASE INHIBITOR OF HEPATITIS C VIRUS

PROBLEM TO BE SOLVED: To provide a new peptide compound having HCV protease inhibition activity and a method for producing the compound, in addition, a pharmaceutical composition containing the compound and a method for using them in treating diseases associated with HCV proteases. SOLUTION: A new c...

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Hauptverfasser: PINTO PATRICK A, ARASAPPAN ASHOK, MCCORMICK JINPING L, WANG HAIYAN, GANGULY ASHIT K, VACCARO HENRY A, BOGEN STEPHANE L, ZHU ZHAONING, SCOTT JEFFREY KEMP, TAMURA SUSAN Y, CHAN TIN-YAU, SAKSENA ANIL K, NJOROGE F GEORGE, BENNETT FRANK, JAO EDWIN E, SANTHANAM BAMA, VENKATRAMAN SRIKANTH, PAREKH TEJAL N, GIRIJAVALLABHAN VIYYOOR MOOPIL, PIKE RUSSELL E, LOVEY RAYMOND G, LIM-WILBY MARGUERITA, ODILE ESTHER LEVY, CHEN KEVIN X, LIU YI-TSUNG
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creator PINTO PATRICK A
ARASAPPAN ASHOK
MCCORMICK JINPING L
WANG HAIYAN
GANGULY ASHIT K
VACCARO HENRY A
BOGEN STEPHANE L
ZHU ZHAONING
SCOTT JEFFREY KEMP
TAMURA SUSAN Y
CHAN TIN-YAU
SAKSENA ANIL K
NJOROGE F GEORGE
BENNETT FRANK
JAO EDWIN E
SANTHANAM BAMA
VENKATRAMAN SRIKANTH
PAREKH TEJAL N
GIRIJAVALLABHAN VIYYOOR MOOPIL
PIKE RUSSELL E
LOVEY RAYMOND G
LIM-WILBY MARGUERITA
ODILE ESTHER LEVY
CHEN KEVIN X
LIU YI-TSUNG
description PROBLEM TO BE SOLVED: To provide a new peptide compound having HCV protease inhibition activity and a method for producing the compound, in addition, a pharmaceutical composition containing the compound and a method for using them in treating diseases associated with HCV proteases. SOLUTION: A new class of HCV protease inhibitors, a pharmaceutical composition containing one or more kinds of the compounds, a method for producing the pharmaceutical composition containing one or more kinds of the compounds, a method for treating, preventing or improving one or more symptoms of hepatitis C, a method for controlling the interaction between HCV polypeptides and HCV proteases, a compound inhibiting HCV NS3/NS4a serine protease activity and a peptide compound including an amino acid sequence from P3 to P2' are disclosed. COPYRIGHT: (C)2010,JPO&INPIT
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language eng
recordid cdi_epo_espacenet_JP2009292832A
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title NEW PEPTIDE AS NS3-SERINE PROTEASE INHIBITOR OF HEPATITIS C VIRUS
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