NEW PEPTIDE AS NS3-SERINE PROTEASE INHIBITOR OF HEPATITIS C VIRUS

PROBLEM TO BE SOLVED: To provide a new peptide compound having HCV protease inhibition activity and a method for producing the compound, in addition, a pharmaceutical composition containing the compound and a method for using them in treating diseases associated with HCV proteases. SOLUTION: A new c...

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Hauptverfasser:	PINTO PATRICK A, ARASAPPAN ASHOK, MCCORMICK JINPING L, WANG HAIYAN, GANGULY ASHIT K, VACCARO HENRY A, BOGEN STEPHANE L, ZHU ZHAONING, SCOTT JEFFREY KEMP, TAMURA SUSAN Y, CHAN TIN-YAU, SAKSENA ANIL K, NJOROGE F GEORGE, BENNETT FRANK, JAO EDWIN E, SANTHANAM BAMA, VENKATRAMAN SRIKANTH, PAREKH TEJAL N, GIRIJAVALLABHAN VIYYOOR MOOPIL, PIKE RUSSELL E, LOVEY RAYMOND G, LIM-WILBY MARGUERITA, ODILE ESTHER LEVY, CHEN KEVIN X, LIU YI-TSUNG
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new peptide compound having HCV protease inhibition activity and a method for producing the compound, in addition, a pharmaceutical composition containing the compound and a method for using them in treating diseases associated with HCV proteases. SOLUTION: A new class of HCV protease inhibitors, a pharmaceutical composition containing one or more kinds of the compounds, a method for producing the pharmaceutical composition containing one or more kinds of the compounds, a method for treating, preventing or improving one or more symptoms of hepatitis C, a method for controlling the interaction between HCV polypeptides and HCV proteases, a compound inhibiting HCV NS3/NS4a serine protease activity and a peptide compound including an amino acid sequence from P3 to P2' are disclosed. COPYRIGHT: (C)2010,JPO&INPIT