SUGAR CHAIN-IMMOBILIZED POLYMERIC SUBSTRATE, METHOD FOR PRODUCING THE SAME, AND MEDICAL DEVICE

PROBLEM TO BE SOLVED: To provide a sugar chain-immobilized polymeric substrate with a high safety and blood compatibility, having a high performance in adsorptive removal ability to a verotoxin, particularly a VT2 type verotoxin with a high toxicity, and to provide a method for producing the same an...

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Hauptverfasser:	MIURA HIROSHI, NISHIYAMA TOSHINORI, MATSUDA TOMOMASA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SEPARATION THEIR PREPARATION OR CHEMICAL WORKING-UP THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a sugar chain-immobilized polymeric substrate with a high safety and blood compatibility, having a high performance in adsorptive removal ability to a verotoxin, particularly a VT2 type verotoxin with a high toxicity, and to provide a method for producing the same and a medical device using the sugar chain-immobilized polymeric substrate. SOLUTION: The sugar chain-immobilized polymeric substrate is produced by bonding a polymeric substrate having a methylene group in the molecule to a polymeric chain of a repeating unit (A) having bonded sugar chain thereto in an amount of 0.01-1 (μmol/cm2) per unit area of the substrate. The method for producing the polymeric substrate and the medical device using the sugar chain-immobilized polymeric substrate are included. COPYRIGHT: (C)2010,JPO&INPIT