TRANSGENIC ANIMAL FOR DIFFERENT GENE AND THEIR USE FOR GENE CHARACTERIZATION

PROBLEM TO BE SOLVED: To provide a new gene disruption, and compositions and methods associated therewith. SOLUTION: Disclosed are transgenic animals, as well as compositions and methods relating to the characterization of gene function. Such in vivo studies and characterizations may provide valuabl...

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Hauptverfasser: JUNGE HARALD, STALA JOY ANNE, WILLIS-SEVAUX TRACY ELLEN, VOGEL PETER, MASSEY ERIN MARIE, MCLAIN DINA REBECCA, QIAN NI NANCY, DESAUVAGE FREDERIC, HORNER ALLISON ANNE BYERS, CULBERTSON LING LING, COMBS KATHERIN E, PHILLIPS HEIDI, MONTGOMERY CHARLES A, EDWARDS JOEL, JUNUTULA JAGATH REDDY, SHI ZHENG-ZHENG, YE WEILAN, GIRGIS ROSEMARY, RANGEL CAROLINA, SPARKS MARY JEAN, PAYNE BOBBY JOE, DING ZHIYONG
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Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a new gene disruption, and compositions and methods associated therewith. SOLUTION: Disclosed are transgenic animals, as well as compositions and methods relating to the characterization of gene function. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, remission or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. COPYRIGHT: (C)2010,JPO&INPIT