METHOD FOR PRODUCING AMINO ALCOHOL DERIVATIVE, AND ITS (1R, 4S)-4-[(2-AMINO-6-CHLORO-5-FORMAMIDE-4-PYRIMIDINYL) AMINO]-2-CYCLOPENTENYL-1-METHANOL

PROBLEM TO BE SOLVED: To provide a new method for producing a racemic form or an optically active form of an amino alcohol expressed by formula I, starting from 2-azabicyclo[2.2.1]hept-5-ene-3-one, a method for converting the above to a corresponding acyl derivative and a method for further converti...

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Hauptverfasser:	RODUIT JEAN-PAUL, BRIEDEN WALTER DR, BERNEGGER-EGLI CHRISTINE, PETERSEN MICHAEL DR, BERCHTOLD KATJA, BREITBACH HOLGER DR, SCHROEER JOSEF DR, URBAN EVA-MARIA
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new method for producing a racemic form or an optically active form of an amino alcohol expressed by formula I, starting from 2-azabicyclo[2.2.1]hept-5-ene-3-one, a method for converting the above to a corresponding acyl derivative and a method for further converting the acyl derivative to its (1S, 4R)- or (1R, 4S)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentenyl-1-methanol. SOLUTION: In the synthesis of the latter, the amino alcohol is converted to a corresponding D- or L-tartaric acid salt, then it is reacted with N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide to make (1S, 4R)- or (1R, 4S)-4-[(2-amino-6-chloro-5-formamide-4-pyrimidinyl)amino]-2-cyclopentenyl-1-methanol. COPYRIGHT: (C)2010,JPO&INPIT