ELECTROCHEMICALLY ACTIVE COMPOUND

PROBLEM TO BE SOLVED: To provide a method of probing for a nucleic acid and comprising: bringing a nucleic acid solution into contact with an oligonucleotide probe labeled with an electrochemically active marker; providing conditions at which the probe is able to at least partially hybridize with an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KEAY RUSSELL, BRAVEN HELEN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method of probing for a nucleic acid and comprising: bringing a nucleic acid solution into contact with an oligonucleotide probe labeled with an electrochemically active marker; providing conditions at which the probe is able to at least partially hybridize with any complementary target sequence which may be present in the nucleic acid solution; selectively degrading either hybridized, partially hybridized or unhybridized nucleic acid probe; and electrochemically determining information relating to the electrochemically active marker, and further to provide a new molecule with use in the method. SOLUTION: A compound with a specific structure comprises an oligonucleotide having a labeled atomic group and a sequence hybridizable to a target. COPYRIGHT: (C)2009,JPO&INPIT