CRYSTAL OF (1S)-1,5-ANHYDRO-1-[5-(4-ETHOXYBENZYL)-2-METHOXY-4-METHYLPHENYL]-1-THIO-D-GLUCITOL, AND METHOD FOR PREPARING THE SAME

PROBLEM TO BE SOLVED: To provide a method of preparing a crystal of (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol which is stable in an environment wherein the compound is used as a medicine, and a crystal of (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-met...

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Bibliographische Detailangaben
Hauptverfasser: SAKUTE TARO, OGINO NARUMI, NISHIMURA CHIENO, MANNAKA AKIRA
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method of preparing a crystal of (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol which is stable in an environment wherein the compound is used as a medicine, and a crystal of (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol having a specific crystal structure that enables the rapid elution thereof as a solid pharmaceutical preparation, and a method for preparing the same. SOLUTION: Disclosed is a method of preparing a crystal having at least one of the following physical properties (a) to (c) as described below, which method is characterized by comprising a process of dissolving a (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol into a liquid mixture of water and an organic solvent having characteristics of intermingling with water, a process of subsequently crystallizing the same at a temperature of 5 to 70°C, and a process of drying the resulting crystal at a temperature of not higher than 50°C. (a) Its powder X-ray diffraction spectrum (Cu-Kα) has peaks at diffraction angles 2θ=3.2°, 9.6°, 11.1°, and 15.5°; (b) its infrared absorption spectrum has characteristic absorption bands at 2,977 cm-1, 1,510 cm-1, 1,244 cm-1, 1,091 cm-1, 1,053 cm-1and 773 cm-1; and (c) its melting point is 156 to 160°C. COPYRIGHT: (C)2009,JPO&INPIT