METHOD OF SCREENING FOR COMPOUNDS INHIBITING BIOSYNTHESIS OF GPI IN MALARIA PARASITES

PROBLEM TO BE SOLVED: To provide a degenerate mutant DNA encoding a protein involved in glycosylphosphatidylinositol (GPI) biosynthesis with a decreased AT content compared to an original DNA encoding a protein involved in GPI biosynthesis, and a method of screening for an antimalarial drug using th...

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Hauptverfasser:	OGAWA KAORU, AINE YASUSHI, HATA KATSURA, NAKAMOTO KAZUTAKA, TSUKADA ITARU, TANAKA KEIGO, TSUKAHARA KATSUHEI, HORII TOSHIHIRO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a degenerate mutant DNA encoding a protein involved in glycosylphosphatidylinositol (GPI) biosynthesis with a decreased AT content compared to an original DNA encoding a protein involved in GPI biosynthesis, and a method of screening for an antimalarial drug using the degenerate mutant DNA. SOLUTION: Provided are a DNA encoding a protein having activity of GPI acyltransferase which is one of GPI biosynthesis enzyme in a falciparum malaria parasite, a protein encoded by the DNA, a transformant holding a vector inserted with the DNA in expressable form (particularly, a yeast deficient in GPI synthase gene), and a method of screening for antimalarial drugs using the protein and transformant. COPYRIGHT: (C)2009,JPO&INPIT