PACKAGING CELL LINE FOR USE IN FACILITATING DEVELOPMENT OF HIGH-CAPACITY ADENOVIRUS VECTOR

PROBLEM TO BE SOLVED: To provide a method for doubling the cell receptor bond and DNA transportation characteristics of original adenovirus virion and, accordingly, improving the genetic therapy and antisense-base antiviral therapy. SOLUTION: Provided are gene therapy, especially to adenovirus-based...

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Hauptverfasser: NEMEROW GLEN R, VON SEGGERN DANIEL J
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creator NEMEROW GLEN R
VON SEGGERN DANIEL J
description PROBLEM TO BE SOLVED: To provide a method for doubling the cell receptor bond and DNA transportation characteristics of original adenovirus virion and, accordingly, improving the genetic therapy and antisense-base antiviral therapy. SOLUTION: Provided are gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, new packaging cell lines are disclosed, for use in facilitating the development of high-capacity vectors. Also disclosed are a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, there disclosed are methods of preparing and using the disclosed vectors, cell lines and kits. COPYRIGHT: (C)2009,JPO&INPIT
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SOLUTION: Provided are gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, new packaging cell lines are disclosed, for use in facilitating the development of high-capacity vectors. Also disclosed are a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, there disclosed are methods of preparing and using the disclosed vectors, cell lines and kits. 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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title PACKAGING CELL LINE FOR USE IN FACILITATING DEVELOPMENT OF HIGH-CAPACITY ADENOVIRUS VECTOR
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