PACKAGING CELL LINE FOR USE IN FACILITATING DEVELOPMENT OF HIGH-CAPACITY ADENOVIRUS VECTOR

PROBLEM TO BE SOLVED: To provide a method for doubling the cell receptor bond and DNA transportation characteristics of original adenovirus virion and, accordingly, improving the genetic therapy and antisense-base antiviral therapy. SOLUTION: Provided are gene therapy, especially to adenovirus-based...

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Bibliographische Detailangaben
Hauptverfasser:	NEMEROW GLEN R, VON SEGGERN DANIEL J
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for doubling the cell receptor bond and DNA transportation characteristics of original adenovirus virion and, accordingly, improving the genetic therapy and antisense-base antiviral therapy. SOLUTION: Provided are gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, new packaging cell lines are disclosed, for use in facilitating the development of high-capacity vectors. Also disclosed are a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, there disclosed are methods of preparing and using the disclosed vectors, cell lines and kits. COPYRIGHT: (C)2009,JPO&INPIT