CARBAMIC ACID COMPOUND COMPRISING SULFONAMIDE LINKAGE AS HDAC INHIBITOR

PROBLEM TO BE SOLVED: To provide carbamic acid compounds comprising a sulfonamide linkage as HDAC (histone deacetylase) activity inhibitors. SOLUTION: Provided is a compound selected from active carbamic acid compounds of formula (1) (wherein, A is an aryl group; Q1is a covalent bond or an aryl lead...

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Hauptverfasser:	RITCHIE JAMES, LOZA EINARS, GAILITE VIJA, MOORE KATHRYN G, STARCHENKOV IGOR, DIKOVSKA KLARA, HARRIS C JOHN, FINN PAUL W, VORONA MAXIM, ROMERO-MARTIN MARIA-ROSARIO, PISKUNOVA IRINA, KALVINSH IVARS, ANDRIANOV VICTOR, WATKINS CLARE J, DUFFY JAMES E S
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide carbamic acid compounds comprising a sulfonamide linkage as HDAC (histone deacetylase) activity inhibitors. SOLUTION: Provided is a compound selected from active carbamic acid compounds of formula (1) (wherein, A is an aryl group; Q1is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from -S(=O)2NR1- and -NR1S(=O)2-; R1is a sulfonamide substituent; and, Q2is an acid leader group; with the proviso that if J is -S(=O)2NR1-, then Q1is an aryl leader group) and pharmaceutically acceptable salts and solvates thereof. COPYRIGHT: (C)2009,JPO&INPIT