ANTIBODY AGAINST CANCER

PROBLEM TO BE SOLVED: To provide an apoptosis-inducing method for treating cancer cells with an isolated binding partner of a Cripto-1 protein, Pim-1 protein or an antigen existing in a colon cancer cell lysate. SOLUTION: The binding partner inhibits growth of one or more cancer cell types and is ab...

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Bibliographische Detailangaben
Hauptverfasser:	HU XIU FENG, MCKENZIE IAN FARQUAR CAMPBELL, XING PEI XIANG
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an apoptosis-inducing method for treating cancer cells with an isolated binding partner of a Cripto-1 protein, Pim-1 protein or an antigen existing in a colon cancer cell lysate. SOLUTION: The binding partner inhibits growth of one or more cancer cell types and is able to be used as an anti-cancer agent for treating cancer in a subject, and also used in a method for inducing apoptosis in a cancer cell and a method for sensitising a cancer cell to a cytotoxic compound. In addition, a cancer vaccine is provided. The vaccine comprises a Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or an antigen existing in a colon cancer cell lysate, or an expressible DNA molecule encoding the Cripto-1 protein (or an antigenic fragment thereof), Pim-1 protein (or an antigenic fragment thereof) or the antigen existing in a colon cancer cell lysate. COPYRIGHT: (C)2009,JPO&INPIT