PHENOL DERIVATIVE HAVING ACTION FOR INHIBITING AMYLOID BETA AGGREGATION

PHENOL DERIVATIVE HAVING ACTION FOR INHIBITING AMYLOID BETA AGGREGATION

PROBLEM TO BE SOLVED: To provide a compound useful as a preventive and/or therapeutic agent for Alzheimer type dementia. SOLUTION: A phenol derivative expressed by formula (I) (wherein R1expresses H or a halogen atom; R2and R3are independently same or different and express each H or OH, or R2and R3i...

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Hauptverfasser: SUZUKI EIJI, OKUNO HIROAKI, ISHIGAMI AKITO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide a compound useful as a preventive and/or therapeutic agent for Alzheimer type dementia. SOLUTION: A phenol derivative expressed by formula (I) (wherein R1expresses H or a halogen atom; R2and R3are independently same or different and express each H or OH, or R2and R3integrally express a carbonyl group; R4and R5independently express each OH or a 1-6C alkyloxy group; m expresses an integer of 1-5) or formula (II) (wherein X expresses a glutamic acid residue or a tyrosine residue; m expresses an integer of 1-3) or a pharmaceutically permissible salt, hydrate or solvate thereof is provided. COPYRIGHT: (C)2009,JPO&INPIT