FUNGAL CELL WALL SYNTHESIS GENE

PROBLEM TO BE SOLVED: To provide a method for developing an antifungal agent based on a new principle, and to provide the antifungal agent. SOLUTION: A reporter system reflecting the transport process of GPI anchor protein to cell wall is constructed and a compound inhibiting this process is found o...

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Hauptverfasser:	AINE YASUSHI, KAI JUNKO, OBA FUMINORI, HATA KATSURA, UEDA NORIHIRO, TSUCHIYA MAMIKO, NAKAMOTO KAZUTAKA, WATANABE NAOAKI, TSUKADA ITARU, TSUKAHARA KATSUHEI, TANAKA KEIGO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for developing an antifungal agent based on a new principle, and to provide the antifungal agent. SOLUTION: A reporter system reflecting the transport process of GPI anchor protein to cell wall is constructed and a compound inhibiting this process is found out. A gene imparting tolerance to the compound is identified and a method of screening a compound inhibiting the activity of the protein encoded by the gene is developed. Thus, it is clarified by the novel compound that antifungal agents depending on a novel mechanism, wherein the transport process of GPI anchor protein to the cell wall is inhibited, are available. COPYRIGHT: (C)2008,JPO&INPIT