TRIARYL METHANE COMPOUND FOR SICKLE CELL DISEASE

PROBLEM TO BE SOLVED: To provide a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. SOLUTION: The active compounds are substituted triaryl methane compounds or analogues thereof wher...

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Hauptverfasser:	BELLOT EMILE M JR, MOUSSA ADEL M, HAIDAR REEM M, SUN MINGHUA, HALPERIN JOSE, KELLEHER EUGENE W, FROIMOWITZ MARK, TAFT HEATHER N, GAO YING-DUO, KHER FALGUNI M, BRUGNARA CARLO, LOMBARDY RICHARD J, CLIFFORD JOHN J, SACHDEVA YESH P
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation. SOLUTION: The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups are replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. The compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle cell dehydration and/or delay the occurrence of erythrocyte sickling or deformation. COPYRIGHT: (C)2008,JPO&INPIT