ENHANCED PRODUCTION OF TAXANE BY CELL CULTURE OF TAXUS SPECIES

PROBLEM TO BE SOLVED: To provide a method for producing taxol, baccatin III and other taxol-like compounds or taxanes in very high yield from all known Taxus species (e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis). SOLUTION: An enhancement age...

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Bibliographische Detailangaben
Hauptverfasser:	ROACH BRADEN L, PRINCE CHRISTOPHER L, KAKRADE PRAKASH G, BRINGI VENKATARAMAN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for producing taxol, baccatin III and other taxol-like compounds or taxanes in very high yield from all known Taxus species (e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis). SOLUTION: An enhancement agent for enhancing taxane yield, including silver ion or a complex, jasmonic acid (especially the methyl ester), an auxin-related growth regulator, and an inhibitor of the phenylpropanoid pathway (e.g., 3, 4-dimethylenedioxy-6-nitrocinnamic acid) is provided. COPYRIGHT: (C)2008,JPO&INPIT