METHOD FOR PRODUCING (Z)-7-CHLORO-((S)-2,2-DIMETHYLCYCLOPROPANECARBOXAMIDE)-2-HEPTENOIC ACID

METHOD FOR PRODUCING (Z)-7-CHLORO-((S)-2,2-DIMETHYLCYCLOPROPANECARBOXAMIDE)-2-HEPTENOIC ACID

PROBLEM TO BE SOLVED: To provide a new method for producing (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid as the main intermediate for producing cilastatin used as an auxiliary agent for imipenem. SOLUTION: The new method for producing (Z)-7-chloro-((S)-2,2-dimethylcyclopro...

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Bibliographische Detailangaben
Hauptverfasser: JEONG SEON YI, KIM BYUNG HWAN, KOO EON CHEOL, CHO YANG RAI, SHIM YOUNG JI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a new method for producing (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid as the main intermediate for producing cilastatin used as an auxiliary agent for imipenem. SOLUTION: The new method for producing (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoic acid comprises the following rpocess. From a mixture of the E, Z isomers of ethyl 7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoate, ethyl (E)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoate is selectively hydrolyzed by using an acid, and ethyl (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamide)-2-heptenoate is subjected to alkaline hydrolysis and then purified. COPYRIGHT: (C)2008,JPO&INPIT