HUMAN CTLA-8 AND USES OF CTLA-8-RELATED PROTEINS

PROBLEM TO BE SOLVED: To provide new methods for identifying novel cytokines and other secretion factors and to isolate polynucleotides encoding them, and to provide uses of the cytokines. SOLUTION: Polynucleotides encoding human CTLA-8 and human CTLA-8 polypeptides are disclosed. The inhibition of...

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Hauptverfasser:	MI SHA, JACOBS KENNETH, CARLIN MCKEOUGH, GOLDEN-FLEET MARGARET, KELLEHER KERRY, GIANNOTTI JOANN, GOLDMAN SAMUEL, PITTMAN DEBRA, NEBEN STEVEN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide new methods for identifying novel cytokines and other secretion factors and to isolate polynucleotides encoding them, and to provide uses of the cytokines. SOLUTION: Polynucleotides encoding human CTLA-8 and human CTLA-8 polypeptides are disclosed. The inhibition of angiogenesis, inhibition of proliferation of vascular endothelial cells, inhibition of tumor growth, inhibition of angiogenesis-dependent tissue growth, proliferation of myeloid cells or progenitors, proliferation of erythroid cells or progenitors, proliferation of lymphoid cells or progenitors, induction of IFNγ production, the induction of IL-3 production and induction of GM-CSF production are effectively carried out in a subject by using the polynucleotides and the polypeptides. COPYRIGHT: (C)2008,JPO&INPIT