THERAPEUTIC METHOD FOR METABOLIC DISEASE USING MALONYL-COA DECARBOXYLASE INHIBITOR

PROBLEM TO BE SOLVED: To provide a method for treatment of certain metabolic diseases, and to provide the use of a compound and their prodrug, a pharmaceutical composition containing such compound useful in treating such diseases. SOLUTION: The invention relates to the compound and composition for t...

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Hauptverfasser:	WALLACE DAVID, ARRHENIUS THOMAS, SERAFIMOV ROSSY, NISHIMOTO MASAHIRO, CHENG JIE FEI, BROWN STEVE, HARMON CHARLES, TITH SOVOUTHY, WILSON MARK
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for treatment of certain metabolic diseases, and to provide the use of a compound and their prodrug, a pharmaceutical composition containing such compound useful in treating such diseases. SOLUTION: The invention relates to the compound and composition for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity, through the inhibition of malonyl-CoA decarboxylase (MCD). The compound has a structure represented by formula (I) and formula (II), wherein Y is S or O, C is not existing or an optionally substituted single 3-7 membered ring containing 0-3 hetero atoms, R1, R2, R6and R7are each an alkyl group, etc. COPYRIGHT: (C)2008,JPO&INPIT