FLAVIVIRUS EXPRESSION AND DELIVERY SYSTEM

PROBLEM TO BE SOLVED: To provide an improved expression and delivery system of a gene expression. SOLUTION: A system of gene expression and delivery system comprises (a) a replicon of flavivirus origin, substituting a part of nucleotide sequence encoding a structural protein coding region without di...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	VARNAVSKI ANDREI, KHROMYKH ALEXANDER A, WESTAWAY EDWIN G
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an improved expression and delivery system of a gene expression. SOLUTION: A system of gene expression and delivery system comprises (a) a replicon of flavivirus origin, substituting a part of nucleotide sequence encoding a structural protein coding region without disrupting replication capability and capable of inserting an expressible heterologous nucleotide sequence, and including at least a part of flavivirus core protein and (b) at least a second vector that is capable of expressing flavivirus structural protein, required for packaging of the replicon into infectious flavivirus-like particles, and when the replicon is present, the vector is engineered to prevent recombination with the replicon. COPYRIGHT: (C)2008,JPO&INPIT