4'-C-SUBSTITUTED-2-HALOADENOSINE DERIVATIVE

PROBLEM TO BE SOLVED: To create a compound which has excellent anti-HIV activity, particularly is effective for multidrug-resistant HIV strains having resistance to a plurality of anti-HIV drugs such as AZT, DDI, DDC, D4T or 3TC, is low in cytotoxicity, and has resistance to deactivation by adenosin...

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Hauptverfasser:	MATSUOKA MASAO, KODAMA EIICHI, ORUI HIROSHI, KOGO SATORU, MITSUYA HIROAKI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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creator	MATSUOKA MASAO KODAMA EIICHI ORUI HIROSHI KOGO SATORU MITSUYA HIROAKI
description	PROBLEM TO BE SOLVED: To create a compound which has excellent anti-HIV activity, particularly is effective for multidrug-resistant HIV strains having resistance to a plurality of anti-HIV drugs such as AZT, DDI, DDC, D4T or 3TC, is low in cytotoxicity, and has resistance to deactivation by adenosine deaminase. SOLUTION: This invention relates to a 4'-C-substituted-2-haloadenosine derivative represented by formula [I], [II] or [III] (wherein X is halogen; R1is ethynyl or cyano; and R2is hydrogen, the atom of a residue of phosphoric acid or the derivative thereof). The invention also relates to a medicinal composition comprising the derivative and a pharmaceutically acceptable support. COPYRIGHT: (C)2008,JPO&INPIT
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SOLUTION: This invention relates to a 4'-C-substituted-2-haloadenosine derivative represented by formula [I], [II] or [III] (wherein X is halogen; R1is ethynyl or cyano; and R2is hydrogen, the atom of a residue of phosphoric acid or the derivative thereof). The invention also relates to a medicinal composition comprising the derivative and a pharmaceutically acceptable support. 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subjects	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
title	4'-C-SUBSTITUTED-2-HALOADENOSINE DERIVATIVE
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