4'-C-SUBSTITUTED-2-HALOADENOSINE DERIVATIVE

4'-C-SUBSTITUTED-2-HALOADENOSINE DERIVATIVE

PROBLEM TO BE SOLVED: To create a compound which has excellent anti-HIV activity, particularly is effective for multidrug-resistant HIV strains having resistance to a plurality of anti-HIV drugs such as AZT, DDI, DDC, D4T or 3TC, is low in cytotoxicity, and has resistance to deactivation by adenosin...

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Bibliographische Detailangaben
Hauptverfasser: MATSUOKA MASAO, KODAMA EIICHI, ORUI HIROSHI, KOGO SATORU, MITSUYA HIROAKI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SUGARS
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To create a compound which has excellent anti-HIV activity, particularly is effective for multidrug-resistant HIV strains having resistance to a plurality of anti-HIV drugs such as AZT, DDI, DDC, D4T or 3TC, is low in cytotoxicity, and has resistance to deactivation by adenosine deaminase. SOLUTION: This invention relates to a 4'-C-substituted-2-haloadenosine derivative represented by formula [I], [II] or [III] (wherein X is halogen; R1is ethynyl or cyano; and R2is hydrogen, the atom of a residue of phosphoric acid or the derivative thereof). The invention also relates to a medicinal composition comprising the derivative and a pharmaceutically acceptable support. COPYRIGHT: (C)2008,JPO&INPIT