ANTIBACTERIAL PIPERIDINE DERIVATIVES

ANTIBACTERIAL PIPERIDINE DERIVATIVES

PROBLEM TO BE SOLVED: To provide piperidine derivatives which inhibit the DNA gyrase and topoisomerase IV of bacteria and are useful as antibacterial agents. SOLUTION: Compounds of formula (1) [R1 is H, OH, a halogen, or the like; R2 is H, OH, a halogen, or the like; R3 is H, nitro, OH, a halogen, o...

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Hauptverfasser: HAUCK SHEILA IRENE, BASARAB GREG, DANGEL BRIAN, ZHOU FEI, HILL PAMELA, HULL KENNETH GREGORY, GREEN OLUYINKA, MULLEN GEORGE, GRAVESTOCK MICHAEL BARRY, SHERER BRIAN, FLEMING PAUL ROBERT, NI HAIHONG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide piperidine derivatives which inhibit the DNA gyrase and topoisomerase IV of bacteria and are useful as antibacterial agents. SOLUTION: Compounds of formula (1) [R1 is H, OH, a halogen, or the like; R2 is H, OH, a halogen, or the like; R3 is H, nitro, OH, a halogen, or the like; R4 and R5 are each a substituent on carbon, such as a halogen, amino, or carboxy; (n) is 1 to 4; (m) is 0 to 4; W is -O- or the like; X is a direct bond, -CH2-, or the like; ring A is thiazole, pyridine or the like] or their pharmaceutically acceptable salt are useful as antibacterial agents. COPYRIGHT: (C)2008,JPO&INPIT