TREATMENT OF METASTATIC DISEASE

PROBLEM TO BE SOLVED: To provide an antibody inhibiting proliferation of metastatic tumor cells. SOLUTION: A method for preparing an antibody inhibiting proliferation of metastatic tumor cells, comprising (a) injecting tyrosine phosphorylated proteins into lymph nodes of a mammal, (b) harvesting lym...

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Bibliographische Detailangaben
Hauptverfasser:	ZANTEK NICOLE D, KINCH MICHAEL SCOTT, HEIN PATRICK W, KILPATRICK KATHERINE E
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an antibody inhibiting proliferation of metastatic tumor cells. SOLUTION: A method for preparing an antibody inhibiting proliferation of metastatic tumor cells, comprising (a) injecting tyrosine phosphorylated proteins into lymph nodes of a mammal, (b) harvesting lymph node cells from the mammal, (c) fusing the lymph node cells with myeloma cells to form hybridomas, (d) selecting at least one hybridoma producing antibody specifically binding to extracellular epitope of EphA2 and (e) isolating the antibody, is provided. COPYRIGHT: (C)2008,JPO&INPIT