NOVEL METHOD FOR PREPARING OXAZOLIDINONE ANTIBACTERIAL AGENT
PROBLEM TO BE SOLVED: To provide a novel method for preparing an oxazolidinone antibacterial agent. SOLUTION: The novel method for preparing an oxazolidinone antibacterial agent, linezolid, comprises reacting an (S)-1-chloro-3-(benzylidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate...
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| creator | PERRAULT WILLIAM ROLAND REEDER MICHAEL ROBERT IMBORDINO RICK JOSEPH |
| description | PROBLEM TO BE SOLVED: To provide a novel method for preparing an oxazolidinone antibacterial agent. SOLUTION: The novel method for preparing an oxazolidinone antibacterial agent, linezolid, comprises reacting an (S)-1-chloro-3-(benzylidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate, to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield. COPYRIGHT: (C)2008,JPO&INPIT |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NOVEL METHOD FOR PREPARING OXAZOLIDINONE ANTIBACTERIAL AGENT |
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