NOVEL METHOD FOR PREPARING OXAZOLIDINONE ANTIBACTERIAL AGENT

PROBLEM TO BE SOLVED: To provide a novel method for preparing an oxazolidinone antibacterial agent. SOLUTION: The novel method for preparing an oxazolidinone antibacterial agent, linezolid, comprises reacting an (S)-1-chloro-3-(benzylidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate...

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Hauptverfasser:	PERRAULT WILLIAM ROLAND, REEDER MICHAEL ROBERT, IMBORDINO RICK JOSEPH
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a novel method for preparing an oxazolidinone antibacterial agent. SOLUTION: The novel method for preparing an oxazolidinone antibacterial agent, linezolid, comprises reacting an (S)-1-chloro-3-(benzylidenylamino)-propan-2-ol with a morpholinyl fluorophenyl carbamate, to afford a protected imine intermediate which, upon hydrolysis and acylation, yields linezolid in high yield. COPYRIGHT: (C)2008,JPO&INPIT