METHOD AND KIT FOR DETECTING NEUROTOXICITY

PROBLEM TO BE SOLVED: To provide a method and kit for detecting neurotoxicity. SOLUTION: This method for detecting the neurotoxicity of a substance to be tested is provided by comprising (a) a process of exposing the substance to be tested to a nerve-derived cells, (b) a process of measuring the amo...

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Bibliographische Detailangaben
Hauptverfasser:	AKABOSHI HIDEKAZU, YOSHIMURA SAIKO, ISHIHARA MITSUKO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method and kit for detecting neurotoxicity. SOLUTION: This method for detecting the neurotoxicity of a substance to be tested is provided by comprising (a) a process of exposing the substance to be tested to a nerve-derived cells, (b) a process of measuring the amount of expression of at lest one mRNA of specific polynucleotide sequences in the nerve-derived cells, and (c) a process of comparing the measured expressed amount of the mRNA with the expressed amount of the mRNA of the specific polynucleotides in the nerve-derived cells without being exposed to the substance to be tested. Also, the kit for detecting the neurotoxicity is provided by including a nucleic acid consisting of at least 10 continuous sequences capable of hybridizing with a base sequence selected from a group consisting of the specific base sequences and a complemental sequences to the above specific sequences under a stringent condition. COPYRIGHT: (C)2008,JPO&INPIT