PRODUCTION INHIBITOR I FOR GRANULOCYTE/MACROPHAGE COLONY STIMULATING FACTOR (GM-CSF)

PROBLEM TO BE SOLVED: To provide a production inhibitor for GM-CSF having an excellent efficacy for prophylactic and amelioration of rough skin symptoms and inflammations caused by various dermatological disorder such as atopic dermatitis, contact dermatitis, etc., allergic symptoms, rough skin of a normal subject, sensitive skin, and to provide a therapeutic agent for allergic dermatitis containing the production inhibitor for GM-CSF as an active component, a food, a cosmetic, and a skin care composition for prophylactic/amelioration of dry rough skin. SOLUTION: The invention relates to the production inhibitor for GM-CSF comprising, as active components, an extract of leaves and/vines of Wisteria plants, an extract of Euphorbiaceae Alchornea, an extract of Sesamum indicum, an extract of Undraia pinnatifida, a tripeptide comprising lysine-valine-lysine and/or its derivative. The invention also relates to the therapeutic agent for atopic dermatitis, the cosmetic, the food and the skin care preparation formulated with at least one of the production inhibitor for GM-CSF. COPYRIGHT: (C)2007,JPO&INPIT