CENTROMERE-LOCALIZED PROTEIN GENE CONDITIONAL KNOCKOUT CELL

PROBLEM TO BE SOLVED: To provide a centromere-localized protein gene knockout cell. SOLUTION: This tetracycline-responding CENP-K or CENP-M knockout cell, having a gene of CENP-K or CENP-M inserted into the downstream of a promoter responding to tetracycline, lacking functions on the chromosome of t...

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Hauptverfasser:	OKADA KIYOHIRO, FUKAGAWA TATSURO, HORI TETSUYA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a centromere-localized protein gene knockout cell. SOLUTION: This tetracycline-responding CENP-K or CENP-M knockout cell, having a gene of CENP-K or CENP-M inserted into the downstream of a promoter responding to tetracycline, lacking functions on the chromosome of the protein CENP-K or CENP-M which comprises a specific amino acid sequence or the specific amino acid sequence whose one or several amino acids are deleted, replaced or added, is localized in a centromere, and has a binding property to CENP-H or CENP-I. COPYRIGHT: (C)2007,JPO&INPIT