CHIMERA IMMUNOGLOBULIN SPECIFIC TO p55Tac PROTEIN OF IL-2 RECEPTOR

PROBLEM TO BE SOLVED: To provide improved forms of humanized immunoglobulins that are substantially non-immunogenic in humans, yet easily and economically produced in a manner suitable for therapeutic formulations and other uses and provide a pharmaceutical composition for treatment using the compos...

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Bibliographische Detailangaben
Hauptverfasser:	SELICK HAROLD E, QUEEN CARY L
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide improved forms of humanized immunoglobulins that are substantially non-immunogenic in humans, yet easily and economically produced in a manner suitable for therapeutic formulations and other uses and provide a pharmaceutical composition for treatment using the composition. SOLUTION: The present invention relates to a method for producing humanized immunoglobulins having framework regions capable of binding to an antigen with affinity of at least 108M-1and derived from human receptor immunoglobulin light and heavy chains and complementary determining regions (CDR's) derived from a donor immunoglobulin and defined by Kabat, et al. The method includes a step of substituting at least one non-CDR framework amino acid of a receptor immunoglobulin with the corresponding amino acid derived from a donor immunoglobulin and the substitution is carried out at a prescribed position. COPYRIGHT: (C)2007,JPO&INPIT