NUCLEIC ACID CONSTRUCT

PROBLEM TO BE SOLVED: To provide an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. SOLUTION: In effect, these compositions combine chemical modifications and/or ligand additio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ENGELHARDT DEAN L, DONEGAN JAMES J, RABBANI ELAZAR, STAVRIANOPOULOS JANNIS G, KELKER NORMAN E, LIU DAKAI
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. SOLUTION: In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits. COPYRIGHT: (C)2007,JPO&INPIT