NEW PROTEIN AND METHOD FOR PRODUCING MEDICINE BY USING THE SAME

PROBLEM TO BE SOLVED: To provide a protein capable of neutralizing action of TNFα. SOLUTION: The present invention provides a protein having about 42,000 dalton molecular weight in a first glycosylated form and having an amino acid sequence: Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Ar...

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Bibliographische Detailangaben
Hauptverfasser:	HILLEN HEINZ, LEMAIRE HANS-GEORG, DAUM LOTHAR, DOERPER THOMAS, MOELLER ACHIM, SUBKOWSKI THOMAS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a protein capable of neutralizing action of TNFα. SOLUTION: The present invention provides a protein having about 42,000 dalton molecular weight in a first glycosylated form and having an amino acid sequence: Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu [wherein Xaa is a hydrogen atom, a phenylalanine (Phe) group or an amino acid sequence: Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe] and a mutein obtained by suitable substitution, deletion or addition without strongly lowering action of the protein or by changing the glycoside group. COPYRIGHT: (C)2007,JPO&INPIT