METHOD FOR PRODUCING 1-DEOXYGALACTONOJIRIMYCIN, SYNTHETIC INTERMEDIATE AND METHOD FOR PRODUCING THE SAME

METHOD FOR PRODUCING 1-DEOXYGALACTONOJIRIMYCIN, SYNTHETIC INTERMEDIATE AND METHOD FOR PRODUCING THE SAME

PROBLEM TO BE SOLVED: To provide a method for synthesizing 1-deoxygalactonojirimycin in shorter processes and in a high yield. SOLUTION: This method for synthesizing the 1-deoxygalactonojirimycin from 1-deoxynojirimycin comprises a process for protecting the nitrogen and the 6-hydroxyl group of the...

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Bibliographische Detailangaben
Hauptverfasser: TOYODA ASAKO, NAGAI HAZUKI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method for synthesizing 1-deoxygalactonojirimycin in shorter processes and in a high yield. SOLUTION: This method for synthesizing the 1-deoxygalactonojirimycin from 1-deoxynojirimycin comprises a process for protecting the nitrogen and the 6-hydroxyl group of the 1-deoxynojirimycin to obtain a compound represented by formula (II), a process for protecting the 2 and 3-hydroxyl groups of the compound represented by formula (II) to obtain a compound represented by formula (III), a process for sulfonating the 4-hydroxyl group of the compound represented by formula (III) to obtain a compound represented by formula (IV), a process for reversing the 4-position of the compound represented by formula (IV) to obtain a compound represented by formula (V), and a process for removing all the protecting groups of the compound represented by formula (V) to obtain the 1-deoxygalactonojirimycin. COPYRIGHT: (C)2007,JPO&INPIT