RECOMBINANT IL4 ANTIBODIES USEFUL IN TREATMENT OF IL4 MEDIATED DISORDERS

PROBLEM TO BE SOLVED: To provide a high affinity interleukin-4 (IL4) antagonist inhibiting eosinophilic inflammation and further capable of treating, preventing and diagnosing allergic reaction, and use thereof. SOLUTION: Disclosed is a fusion protein having binding specificity for human IL4 which c...

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Hauptverfasser:	HOLMES STEPHEN D, SYLVESTER DANIEL R, GROSS MITCHELL STUART
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a high affinity interleukin-4 (IL4) antagonist inhibiting eosinophilic inflammation and further capable of treating, preventing and diagnosing allergic reaction, and use thereof. SOLUTION: Disclosed is a fusion protein having binding specificity for human IL4 which comprises complementarity determining regions (CDRs) derived from a non-human neutralizing monoclonal antibody characterized by a dissociation constant equal to or less than 2×10-10M for human IL4, and human or humanized framework regions. COPYRIGHT: (C)2007,JPO&INPIT