METHOD FOR PRODUCING BIARYL COMPOUND
PROBLEM TO BE SOLVED: To provide a method for synthesizing a biaryl compound, making it possible that an unstable triarylborane compound is industrially used in a stable form by Suzuki-Miyaura reaction and economically useful. SOLUTION: This method for producing the biaryl compound expressed by Ar1-...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To provide a method for synthesizing a biaryl compound, making it possible that an unstable triarylborane compound is industrially used in a stable form by Suzuki-Miyaura reaction and economically useful. SOLUTION: This method for producing the biaryl compound expressed by Ar1-Ar2(Ar1is phenyl or the like; and Ar2is phenyl or the like) comprises reacting any one of a triarylboron amine complex expressed by Ar13B-NR1R2R3(R1, R2and R3are each H, an aklyl or the like) and an organic boron-alkali metal hydroxide adduct expressed by Ar13B-WOH (W is Na or the like) with an aromatic or unsaturated heterocyclic compound expressed by Ar2X (Ar2is phenyl or the like; and X is a halogen or the like) in the presence of a transition metal-based catalyst expressed by MYnLmand, if necessary, a phosphine ligand and in the coexistence of a base. COPYRIGHT: (C)2007,JPO&INPIT |
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