POLYPEPTIDE CRYSTAL AND METHOD FOR DESIGNING INHIBITORY AGENT

PROBLEM TO BE SOLVED: To provide a useful technology for designing Aspergillus fumigatus-derived NMT(N-myristoyltransferase)-inhibitory agent by crystallizing Aspergillus fumigatus-derived NMT to obtain a three-dimensional structure through subjecting the resultant crystal to X-ray crystallography....

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Bibliographische Detailangaben
Hauptverfasser:	NAGATA CHIKAHIRO, SUZUKI MAKOTO, SUGIMORI MASAMICHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a useful technology for designing Aspergillus fumigatus-derived NMT(N-myristoyltransferase)-inhibitory agent by crystallizing Aspergillus fumigatus-derived NMT to obtain a three-dimensional structure through subjecting the resultant crystal to X-ray crystallography. SOLUTION: The technology comprises obtaining crystal comprising a polypeptide composed of at least part of an amino acid sequence of Aspergillus fumigatus-derived NMT or an amino acid sequence where one or more amino acids are deleted, substituted, inserted or added in the above amino acid sequence, or the three-dimensional structure of the polypeptide. A method for designing the Aspergillus fumigatus-derived NMT-inhibitory agent is provided based on the three-dimensional structure data. COPYRIGHT: (C)2007,JPO&INPIT