COMPOUND FOR SUPPRESSING HIV-TAT TRANSACTIVATION

PROBLEM TO BE SOLVED: To provide a compound for suppressing HIV-TAT transactivation. SOLUTION: The compound is expressed by structural formula (R1, R2, R3and R4are each selected from a group consisting of HO-, CH3O- and CH3(C=O)O- provided that R1, R2, R3and R4are not HO- at the same time). Each com...

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Bibliographische Detailangaben
Hauptverfasser:	HUANG RU CHIH, GNABRE JOHN N
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a compound for suppressing HIV-TAT transactivation. SOLUTION: The compound is expressed by structural formula (R1, R2, R3and R4are each selected from a group consisting of HO-, CH3O- and CH3(C=O)O- provided that R1, R2, R3and R4are not HO- at the same time). Each compound is separated from the extract of leaves and flowers of Larrea tridentata which is a kind of creosote bush and is a derivative of 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane (nordihydroguiaiaretic acid, NDGA). The NDGA and its derivative can be used for suppressing the Tat transactivation of lentivirus including HIV virus in a cell by administering the NDGA or its derivative to the cell. COPYRIGHT: (C)2007,JPO&INPIT